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One of the known adverse effects of PUVA treatment is the formation of blisters, which can be spontaneous and self-limiting or can be secondary to a phototoxic reaction, PUVA-induced bullous pemphigoid, or pseudoporphyria.1,3 We describe the clinical and histological characteristics of self-limiting blisters that developed during PUVA treatment of 5 patients at the Phototherapy Unit of the University Hospital of Cabuees